Autotaxin as a marker for liver fibrosis in chronic HCV patients

Document Type : Original Article

Authors

1 Clinical Pathology Department, Al-Mahalla Chest Hospital, Gharbia, Egypt.

2 Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

3 Hepatogastroenterology and Infectious Diseases Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.

Abstract

ABSTRACT:
Background: Chronic hepatitis C is a major health problem. Noninvasive markers were developed to overcome liver biopsy complications. Autotaxin (ATX) is a lysophospholipase D enzyme that regulates lysophosphatidic acid (LPA) blood concentrations. Studies have suggested that the phenotypic changes during liver fibrosis may lead to changes in ATX level in the serum.
Objectives: to determine the serum Autotaxin levels and its correlation to the liver fibrosis and whether it can be used as a non-invasive diagnostic biomarker of fibrosis in Egyptian Chronic viral hepatitis C individuals.
Methodology: This study was conducted on 40 patients divided into 2 groups: Group I comprised of 20 patients with chronic viral hepatitis C patients in compensated stage and Group II comprised of 20 patients with chronic viral hepatitis C patients in decompensated stage together with 20 apparently healthy controls group. All patients were subjected to the following: complete history taking، complete clinical examination، routine lab investigations، abdominal ultrasound and measurement of serum ATX level detected by ELISA technique.
Results: 40 patients were enrolled. Serum ATX was significantly higher according to liver fibrosis worsen stage (p=0.002) ،ATX was significantly higher in decompensated chronic hepatitis C patients (CHC) compared to patients with compensated CHC and controls with mean values (646.7 ± 247.4) ، (615.3 ± 266) and (469.9 ± 62.3) ng/ml respectively (p=0.005).
Conclusion: Autotaxin was shown to be a potential serum marker for estimating the degree of fibrosis in patients with chronic HCV.

Keywords

Journal of Recent Advances in Medicine
Volume 2, Issue 2
July 2021
Pages 142-148

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