Angiotensin converting enzyme gene polymorphism in dyslipidemia and hypertension

Document Type : Original Article

Authors

1 Clinical Pathology Department , Student Hospital, Helwan University, Helwan, Egypt.

2 Clinical Pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.

Abstract

ABSTRACT
Background: Hypertension and dyslipidemia have a multifactorial background based on genetic and environmental interactive factors. Increasing blood pressure (BP) and hypertension incidence have also been found to be linked with elevated blood lipids rates. Insertion/deletion (I/D) polymorphisms of the angiotensin converting enzyme (ACE) are said to be linked to pathogenesis of both hypertension and dyslipidemia.  
Objectives: to investigate the presence of the three genotypes of ACE gene (I/D) polymorphisms with hypertension and dyslipidemia.
Subjects and methods: Participants included 30 Egyptian patients with hypertension and /or dyslipidaemia (Group I) and 20 apparently healthy controls (Group II). For all participants, DNA was isolated and amplified by polymerase chain reaction (PCR); the product was recognized by gel electrophoresis according to their size.
Results: diferent ACE genotypes frequencies were detected according to the presence or absence of 287 bp fragment in intron 16; 30% for Deletion/Deletion  (DD), 56.7%  for Insertion/Deletion (ID) and 13.3% for  Insertion/Insertion (II) in patients group, denoting that (I) allele has a significant association with hypertension and dyslipidemia (p < 0.05).
Conclusions: There is increased frequency of ACE I/D and I/I, therefore, the I allele was common among Egyptian patients affected with hypertension and /or dyslipidaemia.

Keywords

Journal of Recent Advances in Medicine
Volume 2, Issue 1
January 2021
Pages 30-36

Files

Share

How to cite

Statistics